Wyatt

Wyatt Technology Corporation is the leading provider of advanced tools for the characterization of macromolecules and nanoparticles in solution, measuring absolute molar mass, size, charge and interactions.

Their technology includes the finest instruments and software available for:

• Chromatographic and composition-gradient multi-angle static light scattering
• High-throughput dynamic light scattering
• Field flow fractionation
• Differential refractometry
• Electrophoretic mobility
• Differential viscometry

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Best selling Products

DAWN HELEOS II

The world’s most advanced light scattering instrument for absolute characterization of proteins, conjugates, macromolecules, and nanoparticles.

The DAWN HELEOS II is the premier Multi-Angle static Light Scattering (MALS) detector for absolute characterization of the molar mass and size of macromolecules and nanoparticles in solution, offering the highest sensitivity and widest range of molecular weight, size and concentrations. It is most often used in conjunction with Size Exclusion Chromatography (SEC-MALS) or Field-Flow Fractionation (FFF-MALS) to determine distributions of mass, size and composition independent of column calibration by reference standards.

Included with each DAWN is a copy of ASTRA, the most versatile software package available for analysis of online multi-angle and dynamic light scattering.

DynaPro Plate Reader II

High-throughput, automated, temperature-controlled Dynamic Light Scattering.

Revolutionize your performance by replacing your conventional, cuvette-based dynamic light scattering unit with the automated DynaPro Plate Reader II. The DynaPro excels at high-throughput sizing and screening of pharmaceutical and nanoparticle formulations to enable novel workflows that simply would not be possible with other DLS instruments. Even if you need to run just a handful of samples, it’s a great productivity booster.

Included with each DynaPro Plate Reader is a copy of DYNAMICS, our powerful software package for analyzing automated batch dynamic light scattering.

Optilab T-rEX

Universal Detection for Chromatography and FFF Separations

Independent of chromaphores or fluorophores, differential Refractive Index (dRI) detectors serve as accurate and versatile concentration detectors in all types of solvents. dRI is part of standard instrumentation for a variety of macromolecular characterization techniques including standard chromatography, SEC-MALS, FFF-MALS and CG-MALS.

The Optilab T-rEX (refractometer with EXtended range) is a unique dRI detector for standard HPLC/GPC with 256 times the detection power and 50 times the dynamic range of every other RI detector for chromatography in existence today, making it a valuable addition to any MALS setup.

ViscoStar II

The ViscoStar II is a new generation of online differential viscometers.

A highly sensitive, on-line differential viscometer used in conjunction with SEC-MALS to determine the size and conformation of all types of biopolymers and synthetic polymers.

DynaPro NanoStar

Coupled with the versatile and user-friendly DYNAMICS software, the NanoStar may be utilized to measure not just size, size distributions, and weight-average molar mass, but also solution properties relevant to sample stability: the second virial coefficient (A2 or B22), the diffusion interaction parameter (kD or D1, closely related to the second virial coefficient), and the temperature of protein melting or aggregation onset (TM, Tonset).

Mobius

The Möbiuζ offers a unique suite of capabilities for mobility and size measurements of proteins, polymers and nanoparticles:

Non-destructive analysis of fragile biomolecules Repeatable and accurate measurements in conductive buffers such as physiological saline Simultaneous measurements of size and mobility Automated sample handling or manual measurements Fluorescence blocking filter for sizing of fluorescing nanoparticles such as quantum dots The Möbiuζ characterizes the mobility of proteins and other biomolecules non-destructively and robustly, thanks to an innovative design enabling some unprecedented capabilities described more fully in the Advanced Technology tab.

Eclipse AF4

Versatile separations of polymers, proteins, colloids, and nanoparticles.

Flow Field-Flow Fractionation is a uniquely versatile means of size-based separations, capable of fractionating and characterizing proteins and aggregates, liposomes, emulsions, viral particles, polysaccharides, nanoparticles, polymer latex particles, colloidal soil suspensions, chemical mechanical polishing slurries, and many more – with no stationary phase and almost no shear.

The Eclipse AF4 supports all AF4 techniques except Hollow-Fiber Flow Field-Flow Fractionation (HF5), which is covered by the Eclipse DualTec. However, the Eclipse AF4 supports the fritless AF4 channel which prevents the difficulties encountered by certain samples prone to aggregation at the relatively high concentrations typical of the AF4 focusing step.

CALYPSO

The CALYPSO software uses CG-MALS data to calculate the affinity and stoichiometry of specific, reversible complexes formed in solution, such as antibody-antigen interactions and protein dimerization. The software enables quick data fitting to simple models of dimer formation, 1:n stoichiometries, and infinite self-association. Alternatively, the highly versatile analysis tools allow you to choose and design more complex binding schemes, including simultaneous self- and hetero-association, cooperativity, and meta-complex formation.